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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEK2
All Species:
49.39
Human Site:
S241
Identified Species:
77.62
UniProt:
P51955
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51955
NP_002488.1
445
51763
S241
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
Chimpanzee
Pan troglodytes
XP_514178
522
59597
S318
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
Rhesus Macaque
Macaca mulatta
XP_001108740
445
51674
S241
R
R
I
P
Y
R
Y
S
D
E
L
N
G
I
I
Dog
Lupus familis
XP_537144
668
75595
S465
R
R
I
P
Y
R
Y
S
D
E
L
N
D
I
I
Cat
Felis silvestris
Mouse
Mus musculus
O35942
443
51289
S241
R
R
I
P
Y
R
Y
S
D
G
L
N
D
L
I
Rat
Rattus norvegicus
XP_001055166
443
51340
S241
R
R
I
P
Y
R
Y
S
D
G
L
N
D
L
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509538
499
57433
S295
R
R
I
P
H
R
Y
S
D
Q
L
N
D
V
L
Chicken
Gallus gallus
NP_001026221
444
51581
S240
R
R
I
P
Y
R
Y
S
E
Q
L
N
E
L
L
Frog
Xenopus laevis
NP_001079490
442
52004
S241
R
R
I
P
Y
R
Y
S
E
E
L
N
Q
V
I
Zebra Danio
Brachydanio rerio
Q90XC2
697
76523
S228
A
P
I
S
D
R
Y
S
P
E
L
R
Q
L
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572415
735
82962
S251
S
R
I
P
A
I
Y
S
T
D
L
Q
E
I
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786794
453
51921
S240
R
R
L
P
V
Q
Y
S
S
D
L
N
E
I
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9CAU7
606
68016
S228
P
P
L
P
A
Q
Y
S
A
A
F
R
G
L
V
Baker's Yeast
Sacchar. cerevisiae
P22209
435
51185
V249
I
Q
F
A
T
T
Y
V
G
T
P
Y
Y
M
S
Red Bread Mold
Neurospora crassa
P48479
858
94329
S260
A
P
L
P
S
V
Y
S
G
E
L
F
A
T
I
Conservation
Percent
Protein Identity:
100
85
98.4
62.5
N.A.
87.6
89.4
N.A.
69.7
77
73.9
25.8
N.A.
30.2
N.A.
N.A.
54.3
Protein Similarity:
100
85
99.3
65.4
N.A.
94.1
95
N.A.
80.9
88.7
86.7
39
N.A.
44.3
N.A.
N.A.
72.1
P-Site Identity:
100
100
93.3
93.3
N.A.
80
80
N.A.
66.6
73.3
80
46.6
N.A.
60
N.A.
N.A.
60
P-Site Similarity:
100
100
93.3
100
N.A.
93.3
93.3
N.A.
100
100
100
60
N.A.
66.6
N.A.
N.A.
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
27.2
22.7
24.3
Protein Similarity:
N.A.
N.A.
N.A.
44.8
43.8
36.1
P-Site Identity:
N.A.
N.A.
N.A.
20
6.6
40
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
20
46.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
0
0
7
14
0
0
0
7
7
0
0
7
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
7
0
0
0
47
14
0
0
27
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
14
47
0
0
34
0
0
% E
% Phe:
0
0
7
0
0
0
0
0
0
0
7
7
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
14
14
0
0
14
0
0
% G
% His:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
0
74
0
0
7
0
0
0
0
0
0
0
40
67
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
20
0
0
0
0
0
0
0
87
0
0
34
14
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
67
0
0
0
% N
% Pro:
7
20
0
87
0
0
0
0
7
0
7
0
0
0
0
% P
% Gln:
0
7
0
0
0
14
0
0
0
14
0
7
14
0
0
% Q
% Arg:
67
74
0
0
0
67
0
0
0
0
0
14
0
0
0
% R
% Ser:
7
0
0
7
7
0
0
94
7
0
0
0
0
0
7
% S
% Thr:
0
0
0
0
7
7
0
0
7
7
0
0
0
7
0
% T
% Val:
0
0
0
0
7
7
0
7
0
0
0
0
0
14
14
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
54
0
100
0
0
0
0
7
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _